The Active ingredients in Thera-P Complete - based on scientific research mentioned below - help with:
Each Enteric Coated Capsule from Thera-P Complete™ contains 200 mg of standardized powdered extract of Horse Chestnut (Aesculus hippocastanum), Aescin.
Aescin is the same active ingredient in Reparil tablet 20 mg & 40 mg (Reparil is Registered Trademark, manufactured originally by MADAUS GmbH, GERMANY, now under Mylan, sold in Europe, the Middle East and Asia.
Mechanism of Action
The target site of Aescin is the vascular wall. In pathologically raised permeability, Aescin inhibits exudation by reducing the extravasation of fluid into the tissue and accelerating the subsidence of oedema. The mode of action is based on changes in the permeability of the affected capillary walls. In addition, Aescin raises capillary resistance, inhibits inflammatory processes and improves microcirculation.
○ Traumatic swellings (sports injuries)
○ Postoperative pain and edema
○ Painful lesions of the vertebral column
○ Venous Insufficiency
○ Leg edema
○ Varicose veins
○ Leg ulcers
○ Male fertility especially due to Varicose Veins
The most commonly cited adverse effect includes nausea and stomach discomfort, which is minimized by the use of film-coated tablets or enteric Coated Capsule as our product has. Other mild and infrequent complaints include headache, dizziness, and pruritus.
- Avoid use in case of Allergy to any of the capsule components.
- Infants and Children
- Avoid use in Pregnancy/Lactation: Horse chestnut seed extract has been used in clinical trials including pregnant women with no apparent ill effects; however, in the absence of specific safety data, use in pregnancy or lactation is not recommended. Consult your physician first.
- Renal or hepatic impairment may be relative contraindications to the use of aescin or horse chestnut derivatives. Consult your physician first.
- Should not be administered with other nephrotoxic drugs such as gentamicin.
- Infants and Children
- The coumarin derivatives found in horse chestnut extracts may potentiate warfarin, as well as interfere with highly plasma-bound drugs, CYP34A metabolism and P-glycoprotein transport mechanisms of other drugs. Consult your physician first.
- Because hypoglycemic effects have been reported, asecin preparations should be used with caution in persons with diabetes.
For full details please read this article: https://www.drugs.com/npp/horse-chestnut.html#23152216
From: US National Library of Medicine, National Institutes of Health website:
"Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells Molecular Mechanism for Cellular Response to β-Escin and Its Therapeutic Implications β-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation Escin Ia suppresses the metastasis of triple-negative breast cancer by inhibiting epithelial-mesenchymal transition via down-regulating LOXL2 expression β-escin reverses multidrug resistance through inhibition of the GSK3β/β-catenin pathway in cholangiocarcinoma"
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.